keratosis

Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html

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Study Counts

Type	Study_count
Total_Studies	253
interventional	230
Observational	22
Registry	1

Studies over Time by Start Date

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Interventional Trials

Intervention Type

intervention_type	Study_Count
Drug	123
Drug|placebo	30
Procedure	13
Device	10
Device|Drug	10
Drug|Other	9
Other	8
Drug|Procedure	6
Device|Procedure	3
Device|Drug|Other	2
Device|Drug|Procedure	2
Device|Drug|Radiation	2
Diagnostic Test	2
Dietary Supplement	2
Behavioral|Device	1
Combination Product	1
Device|Drug|Other|placebo	1
Device|Other|Procedure	1
Dietary Supplement|placebo	1
Drug|Other|placebo	1
Drug|placebo|Procedure	1
Other|placebo	1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Yearly studies for each intervention by start date

Studies by Country

Country	Study_Count
United States	110
Germany	19
NA	16
Bangladesh	9
Australia	6
United States|Australia	6
Brazil	5
Denmark	5
Korea, Republic of	5
Canada	4
Taiwan	4
United Kingdom	4
China	3
Finland	3
Italy	3
France	2
Norway	2
United States|Canada	2
United States|Puerto Rico	2
Australia|Canada|France|Germany|United Kingdom	1
Australia|Germany	1
Australia|New Zealand	1
Austria|Denmark|Germany|Iceland|United Kingdom	1
Austria|France|Germany	1
Austria|Germany	1
Canada|United States	1
Denmark|Germany|Norway|Sweden|United Kingdom	1
France|Germany	1
France|Germany|Netherlands|Spain|Sweden	1
France|Germany|United Kingdom	1
Germany|Greece	1
Germany|Switzerland	1
Germany|United Kingdom	1
Israel	1
Lithuania	1
Netherlands	1
Sweden	1
Switzerland	1
United States|Germany	1

Sites per Study

Site_count	Study_Count
1	147
2	7
3	7
4	6
5	1
6	4
7	3
8	3
9	3
10	3
11	3
13	4
14	1
16	2
17	3
18	3
19	1
20	4
21	3
22	1
23	2
24	2
25	1
26	4
27	1
28	1
30	3
31	1
32	1
35	1
40	1
46	1
57	1
61	1

Phase

Phase	Study_Count
Phase 3	61
Phase 2	55
N/A	44
Phase 4	31
Phase 1	29
Phase 1/Phase 2	7
Phase 2/Phase 3	2
Early Phase 1	1

Number of Arms

Number_of_Arms	Count_of_Studies
1	44
2	97
3	43
4	18
5	4
7	1
8	4
10	1
NA	18

Enrollment Metrics by Phase

Measure	Early.Phase.1	N.A	Phase.1	Phase.1.Phase.2	Phase.2	Phase.2.Phase.3	Phase.3	Phase.4
Min.	132	7.00000	2.0000	14.0000	12.00000	47.00	12.0000	9.0000
1st Qu.	132	21.75000	24.0000	36.0000	30.00000	95.25	129.0000	20.5000
Median	132	33.00000	45.0000	220.0000	60.00000	143.50	367.0000	47.0000
Mean	132	74.88636	90.2069	166.4286	86.58491	143.50	332.4098	132.6129
3rd Qu.	132	63.00000	79.0000	269.5000	119.00000	191.75	470.0000	235.5000
Max.	132	461.00000	443.0000	320.0000	266.00000	240.00	889.0000	579.0000

Trial Group Type

group_type	Group_Count
Experimental	235
Active Comparator	149
Placebo Comparator	95
Other	19
NA	18
No Intervention	7
Sham Comparator	3

Intervention Model

intervention_model	Study_Count
Parallel Assignment	155
Single Group Assignment	58
Factorial Assignment	6
Sequential Assignment	6
Crossover Assignment	3
NA	2

Primary Purpose

primary_purpose	Study_Count
Treatment	197
Prevention	9
NA	9
Other	7
Diagnostic	5
Health Services Research	2
Basic Science	1

Observational Studies

Studies by Country

Country	Study_Count
United States	7
NA	4
Germany	3
United States|Australia	2
Australia|France|Italy|Netherlands|Spain|Switzerland|United Kingdom	1
Egypt	1
Greece	1
Korea, Republic of	1
Netherlands	1
Norway	1

Sites per Study

Site_count	Study_Count
1	15
6	1
7	1
8	1
11	1
13	1
17	1
42	1

Enrollment Metrics

Measure	Observational
Min	43.0000
1st Qu	98.0000
Median	179.0000
Mean	371.0952
3rd Qu	440.0000
Max	1324.0000

Observation Model

observational_model	Study_Count
Cohort	7
Case-Only	5
NA	5
Other	2
Case-Control	1
Case Control	1
Defined Population, Natural History	1

Time Perspective

time_perspective	Study_Count
Prospective	17
NA	2
Longitudinal, Prospective	1
Other	1
Retrospective	1

Registries

Studies by Country

Country	Study_Count
United States	1

Sites per Study

Site_count	Study_Count
1	1

Enrollment Metrics

Measure	Registries
Min	100
1st Qu	100
Median	100
Mean	100
3rd Qu	100
Max	100

Registry Model

observational_model	Study_Count
Case-Only	1

Time Perspective

time_perspective	Study_Count
Prospective	1

Follow-up

target_duration	Study_Count
6 Months	1

Overview of Studies

Interventional Trials

#If less then 500 trials

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT03826550	Therapeutic Equivalence of Diclofenac Sodium Gel 3% vs Solaraze ® in the Treatment of Actinic Keratosis	https://ClinicalTrials.gov/show/NCT03826550	Completed	Encube Ethicals Pvt. Ltd.	2018-06-30
NCT03325803	Efficacy in Ablative Fractional Laser Assisted Photodynamic Therapy According to Ablative Depth for Actinic Keratosis	https://ClinicalTrials.gov/show/NCT03325803	Completed	Dong-A University	2016-09-30
NCT03322293	Daylight Photodynamic Therapy for Actinic Keratosis	https://ClinicalTrials.gov/show/NCT03322293	Completed	University of California, San Francisco	2018-12-01
NCT03315286	Validation of SHADE a Mobile Technology for Monitoring of Ultraviolet Exposure	https://ClinicalTrials.gov/show/NCT03315286	Completed	Weill Medical College of Cornell University	2019-01-31
NCT03285490	A Multi-Center Study to Evaluate the Efficacy and Safety of KX2-391 Ointment 1% on AK on Face or Scalp (AK004)	https://ClinicalTrials.gov/show/NCT03285490	Completed	Athenex, Inc.	2019-04-30
NCT03285477	A Multi-Center Study to Evaluate the Efficacy and Safety of KX2-391 Ointment 1% on AK on Face or Scalp	https://ClinicalTrials.gov/show/NCT03285477	Completed	Athenex, Inc.	2019-04-30
NCT03246412	Nevus Doctor Clinical Decision Support for GPs	https://ClinicalTrials.gov/show/NCT03246412	Recruiting	University Hospital of North Norway	2020-12-31
NCT03243617	Cosmetic Study of AO+Mist in Improving the Appearance of Skin Afflicted With Keratosis Pilaris	https://ClinicalTrials.gov/show/NCT03243617	Completed	AOBiome LLC	2016-06-08
NCT03200912	An Equivalence Study of Generic Ingenol Mebutate Gel 0.015% and Picato Gel 0.015% in Subjects With Actinic Keratosis	https://ClinicalTrials.gov/show/NCT03200912	Completed	Actavis Inc.	2017-03-07
NCT03127670	Effect of Solanum Melongena Extract in the Treatment of Arsenical Skin Lesion	https://ClinicalTrials.gov/show/NCT03127670	Completed	Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh	2017-12-31
NCT03122457	Perimenstrual Acne With Clindamycin Phosphate and Benzoyl Peroxide	https://ClinicalTrials.gov/show/NCT03122457	Completed	Icahn School of Medicine at Mount Sinai	2018-07-19
NCT03116698	A Study to Evaluate Two Concentrations of DFD-07 Cream, in Subjects With Actinic Keratosis (AK) of the Face and/or Scalp Over a 12-week Treatment Period	https://ClinicalTrials.gov/show/NCT03116698	Completed	Dr. Reddy’s Laboratories Limited	2017-11-13
NCT03076892	Evaluation of Non-inferiority and Tolerability of the Device PHOS-ISTOS	https://ClinicalTrials.gov/show/NCT03076892	Completed	University Hospital, Lille	2017-11-30
NCT03066843	Photodynamic Therapy Incubation Times for Actinic Keratosis	https://ClinicalTrials.gov/show/NCT03066843	Active, not recruiting	Northwestern University	2021-12-31
NCT03037541	Cryosurgery and Cream Combination for Actinic Keratosis	https://ClinicalTrials.gov/show/NCT03037541	Completed	Wake Forest University Health Sciences	2013-10-29
NCT03006185	Laser and Microdermabrasion Before Photodynamic Therapy for Actinic Keratoses in Field-cancerized Skin	https://ClinicalTrials.gov/show/NCT03006185	Completed	Bispebjerg Hospital	2016-11-30
NCT02990221	Efficacy of Ingenol Mebutate on Actinic Keratoses and Field Cancerization vs Cryotherapy	https://ClinicalTrials.gov/show/NCT02990221	Completed	University of Campania “Luigi Vanvitelli”	2018-04-30
NCT02976727	Efficacy of Topical Calcipotriol-assisted AFL-PDT in Actinic Keratosis	https://ClinicalTrials.gov/show/NCT02976727	Completed	Dong-A University	2015-08-31
NCT02952898	Study Comparing GDC 695 and Diclofenac Sodium Gel, 3% in Subjects With Actinic Keratoses	https://ClinicalTrials.gov/show/NCT02952898	Completed	Gage Development Company, LLC	2017-07-11
NCT02938715	Pilot Study of the Pragmatic Use of Mobile Phone Based Follow up of Actinic Keratoses Treated With Topical 5-fluorouracil	https://ClinicalTrials.gov/show/NCT02938715	Completed	University of California, Davis	2017-09-30
NCT02902822	Tele-dermatology of Skin Cancer in a Cohort of Local Health Authority Employees in the Province of Bergamo	https://ClinicalTrials.gov/show/NCT02902822	Completed	Centro Studi Gised	2019-05-31
NCT02878382	Potential Impact of Patient Vitamin D Status in AK Response to MAL-PDT	https://ClinicalTrials.gov/show/NCT02878382	Completed	University of Sao Paulo	2017-01-31
NCT02866695	Safety and Efficacy of Ingenol Mebutate Gel 0.015% for Treatment of AK on the Face in Solid Organ Transplant Recipients	https://ClinicalTrials.gov/show/NCT02866695	Completed	University of California, San Francisco	2018-07-02
NCT02844777	Efficacy and Safety of VDA-1102 Ointment in the Treatment of Actinic Keratosis	https://ClinicalTrials.gov/show/NCT02844777	Completed	Vidac Pharma	2017-05-31
NCT02838628	A Phase 2a, Activity & Safety Study of KX2-391 Ointment in Subjects With Actinic Keratosis on the Face or Scalp	https://ClinicalTrials.gov/show/NCT02838628	Completed	Athenex, Inc.	2016-12-31
NCT02799082	Evaluation of Efficacy and Safety of BF-200 ALA Used With Photodynamic Therapy in Patients With Actinic Keratosis.	https://ClinicalTrials.gov/show/NCT02799082	Completed	Biofrontera Bioscience GmbH	2008-10-31
NCT02799069	Evaluation of Safety and Efficacy of BF-200 ALA for the Treatment of Actinic Keratosis With Photodynamic Therapy	https://ClinicalTrials.gov/show/NCT02799069	Completed	Biofrontera Bioscience GmbH	2009-08-31
NCT02799030	A Clinical Trial of Topical Photodynamic Therapy With 5-aminolevulinic Acid for the Treatment of Actinic Keratosis	https://ClinicalTrials.gov/show/NCT02799030	Completed	Biofrontera Bioscience GmbH	2007-03-31
NCT02759900	Using a Cold Atmospheric Plasma Device to Treat Skin Disorders	https://ClinicalTrials.gov/show/NCT02759900	Recruiting	The Skin Center Dermatology Group	2022-03-31
NCT02716714	Clinical Trial of Ingenol Mebutate Gel 0.015% & 0.05% in Actinic Keratosis	https://ClinicalTrials.gov/show/NCT02716714	Completed	Korea University	2016-06-30
NCT02670655	Efficacy of Iontophoresis-assisted AFL-PDT in Actinic Keratosis	https://ClinicalTrials.gov/show/NCT02670655	Completed	Dong-A University	2015-12-31
NCT02667288	An Open-Label Safety Study of A-101 Solution	https://ClinicalTrials.gov/show/NCT02667288	Completed	Aclaris Therapeutics, Inc.	2016-10-31
NCT02667275	A Randomized, Double-Blind, Vehicle-Controlled Study in Subjects With Seborrheic Keratosis	https://ClinicalTrials.gov/show/NCT02667275	Completed	Aclaris Therapeutics, Inc.	2016-10-31
NCT02667236	A Study of A-101 Solution 40% in Subjects With Seborrheic Keratosis.	https://ClinicalTrials.gov/show/NCT02667236	Completed	Aclaris Therapeutics, Inc.	2016-10-31
NCT02654769	A Study of Equivalence of Generic Ingenol Mebutate Gel 0.05% and Picato Gel 0.05% in Subjects With Actinic Keratosis	https://ClinicalTrials.gov/show/NCT02654769	Completed	Actavis Inc.	2015-09-30
NCT02654717	Eight Week Study of Treatment With DFD-07 for Actinic Keratosis of the Face and Scalp	https://ClinicalTrials.gov/show/NCT02654717	Completed	Promius Pharma, LLC	2016-08-31
NCT02650505	A Clinical Study to Evaluate the Sensitizing Potential of LEO 43204 Gel	https://ClinicalTrials.gov/show/NCT02650505	Completed	LEO Pharma	2016-06-30
NCT02632110	Microneedle Lesion Preparation Prior to Aminolevulinic Acid Photodynamic Therapy (ALA-PDT) for AK on Face	https://ClinicalTrials.gov/show/NCT02632110	Completed	DUSA Pharmaceuticals, Inc.	2016-09-12
NCT02628236	Maximal Use Systemic Exposure Study of Levulan Kerastick (MUSE 2)	https://ClinicalTrials.gov/show/NCT02628236	Completed	DUSA Pharmaceuticals, Inc.	2016-05-31
NCT02622594	Bilateral Comparison of Treatment of Facial Actinic Keratoses Using Microneedling and Photodynamic Therapy With Aminolevulinic Acid and Blue Light Versus Photodynamic Therapy With Aminolevulinic Acid and Blue Light Using Two Incubation Times	https://ClinicalTrials.gov/show/NCT02622594	Completed	Dermatology, Laser & Vein Specialists of the Carolinas	2017-04-13
NCT02616601	Multicenter, Double-blind, Placebo Controlled Comparing Test Fluorouracil Cream to Carac Cream in Actinic Keratosis	https://ClinicalTrials.gov/show/NCT02616601	Completed	Actavis Inc.	2015-09-17
NCT02611804	A Randomized, Double-Blind, Parallel-Group, Vehicle-Controlled, Multicenter Study Comparing Diclofenac Sodium Gel, 3% to Solaraze® Gel, 3% in the Treatment of Actinic Keratosis on the Face or Bald Scalp	https://ClinicalTrials.gov/show/NCT02611804	Completed	Teva Pharmaceuticals USA	2016-08-31
NCT02600598	Biological Effects of LEO 43204 in Actinic Keratosis	https://ClinicalTrials.gov/show/NCT02600598	Completed	LEO Pharma	2016-12-27
NCT02594644	The Use of Microneedles to Expedite Treatment Time in Photodynamic Therapy	https://ClinicalTrials.gov/show/NCT02594644	Completed	University of California, Davis	2016-06-22
NCT02984072	Menthol for PDT Pain Relief	https://ClinicalTrials.gov/show/NCT02984072	Completed	University of Dundee	2019-10-10
NCT02559934	Multiple-dose Pharmacokinetic Study of Solamargine in Patients With Actinic Keratosis	https://ClinicalTrials.gov/show/NCT02559934	Completed	G&E Herbal Biotechnology Co., LTD	2019-01-31
NCT02124733	Protocols for Painless Photodynamic Therapy (PDT) of Actinic Keratoses	https://ClinicalTrials.gov/show/NCT02124733	Completed	The Cleveland Clinic	2016-10-31
NCT02549352	Efficacy and Safety of LEO 43204 in Field Treatment of Actinic Keratosis on Balding Scalp Including 12-month Follow-up	https://ClinicalTrials.gov/show/NCT02549352	Completed	LEO Pharma	2016-09-22
NCT02549339	Efficacy and Safety of LEO 43204 in the Field Treatment of Actinic Keratosis on Face or Chest including12-month Follow-up	https://ClinicalTrials.gov/show/NCT02549339	Completed	LEO Pharma	2016-08-05
NCT03684772	Topical Ionic Contra-Viral Therapy in Actinic Keratosis	https://ClinicalTrials.gov/show/NCT03684772	Recruiting	Maruho Co., Ltd.	2019-09-30
NCT02547363	Efficacy and Safety of LEO 43204 in Field Treatment of Actinic Keratosis on Balding Scalp Including 12-month Follow-up	https://ClinicalTrials.gov/show/NCT02547363	Completed	LEO Pharma	2016-08-17
NCT02547233	Efficacy and Safety of LEO 43204 in Field Treatment of Actinic Keratosis on Face or Chest Including 12-month Follow-up	https://ClinicalTrials.gov/show/NCT02547233	Completed	LEO Pharma	2016-11-30
NCT02520700	A Comparison of White-light and Daylight Topical Methyl 5-aminolaevulinic Acid Photodynamic Therapy for Actinic Keratoses	https://ClinicalTrials.gov/show/NCT02520700	Completed	St Vincent’s University Hospital, Ireland	2015-05-31
NCT02464709	Daylight PDT for Actinic Keratoses: a Multicentre Study Comparing Two Photosensitizers (BF-200 ALA Versus MAL)	https://ClinicalTrials.gov/show/NCT02464709	Completed	Joint Authority for Päijät-Häme Social and Health Care	2017-10-31
NCT02459795	To Compare Safety and Efficacy of Perrigo’s Drug Compared to an FDA Approved Drug in the Treatment of Actinic Keratosis	https://ClinicalTrials.gov/show/NCT02459795	Completed	Perrigo Company	2015-12-31
NCT02451579	A Clinical Trial Evaluating the Role of Systemic Antihistamine Therapy in the Reduction of Adverse Effects Associated With Topical 5-aminolevulinic Acid Photodynamic Therapy	https://ClinicalTrials.gov/show/NCT02451579	Completed	Goldman, Butterwick, Fitzpatrick and Groff	2016-12-31
NCT02446223	Evaluate the Efficacy and Safety of Large-Scale Field-Directed Topical Therapy of Actinic Keratosis of the Chest w/Ingenol Mebutate 0.015%	https://ClinicalTrials.gov/show/NCT02446223	Completed	Goldman, Butterwick, Fitzpatrick and Groff	2016-09-30
NCT02424305	Pharmacokinetics of LEO 43204 Gel in Actinic Keratosis Administered Under Maximal Use Conditions	https://ClinicalTrials.gov/show/NCT02424305	Completed	LEO Pharma	2015-07-31
NCT02411851	Treatment of Actinic Keratoses (AK) on the Face	https://ClinicalTrials.gov/show/NCT02411851	Completed	Icahn School of Medicine at Mount Sinai	2016-06-30
NCT02404389	Safety, Tolerability, and Efficacy Study of LFX453 in Actinic Keratosis Patients	https://ClinicalTrials.gov/show/NCT02404389	Completed	Novartis	2016-01-27
NCT02385318	To Compare Safety and Efficacy of Perrigo’s Drug Product Compared to an FDA Approved Drug Product in the Treatment of Actinic Keratosis	https://ClinicalTrials.gov/show/NCT02385318	Completed	Perrigo Company	2015-12-31
NCT02373371	Actinic Keratoses Treatment With Metvix® in Combination With Light	https://ClinicalTrials.gov/show/NCT02373371	Completed	University Hospital, Limoges	2016-11-22
NCT02361216	Efficacy and Safety of Ingenol Mebutate Gel for Actinic Keratosis Applied on Large Area on Face, Scalp or Chest	https://ClinicalTrials.gov/show/NCT02361216	Completed	LEO Pharma	2016-03-31
NCT02354391	Ingenol Mebutate (Picato®) With Methyl Aminolevulinate Photodynamic Therapy for the Treatment of Actinic Keratosis	https://ClinicalTrials.gov/show/NCT02354391	Active, not recruiting	Pacific Dermaesthetics	2019-12-31
NCT02352987	Effect of Neem Extract, Propylene Glycol and Salicylic Acid Combination in the Treatment of Arsenical Palmar Keratosis	https://ClinicalTrials.gov/show/NCT02352987	Completed	Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh	2015-09-30
NCT02337205	Ph 1, Single-Center, Safety, Tolerability & Pharmacokinetic Study of KX2 391 Ointment in Subj. w Actinic Keratosis	https://ClinicalTrials.gov/show/NCT02337205	Completed	Athenex, Inc.	2016-03-31
NCT02325661	Open Uncontrolled Validation Study for the German Version of the Actinic Keratosis Quality of Life Questionnaire (AKQoL)	https://ClinicalTrials.gov/show/NCT02325661	Completed	University of Zurich	2014-12-31
NCT02305888	Safety of LEO 43204 for Actinic Keratosis Applied on Face/Chest, Scalp and Trunk/Extremities, Respectively	https://ClinicalTrials.gov/show/NCT02305888	Completed	LEO Pharma	2015-07-31
NCT02289768	Study To Evaluate The Efficacy And Safety Of Actikerall® Solution In Patients With Grade I-II Actinic Keratoses	https://ClinicalTrials.gov/show/NCT02289768	Completed	Almirall, S.A.	2015-09-30
NCT02281136	Maximal Use Systemic Exposure (MUSE) Study of Levulan Kerastick	https://ClinicalTrials.gov/show/NCT02281136	Completed	DUSA Pharmaceuticals, Inc.	2015-04-30
NCT02278861	Oral Isotretinoin Versus Topical Tretinoin for Actinic Keratosis	https://ClinicalTrials.gov/show/NCT02278861	Completed	Universidade Federal de Goias	2014-04-30
NCT02260180	Study of A-101 for the Treatment of Seborrheic Keratosis	https://ClinicalTrials.gov/show/NCT02260180	Completed	Aclaris Therapeutics, Inc.	2015-03-31
NCT02251652	Safety and Efficacy of Ingenol Mebutate 0.05% Gel When Used After Cryotherapy in the Hypertrophic Actinic Keratoses	https://ClinicalTrials.gov/show/NCT02251652	Completed	Icahn School of Medicine at Mount Sinai	2014-12-31
NCT02248298	Efficacy of AFL-assisted PDT With Short Incubation Time in Actinic Keratosis	https://ClinicalTrials.gov/show/NCT02248298	Completed	Dong-A University	2014-06-30
NCT02242747	Safety and Tolerability Study of Ingenol Mebutate Compared to 5-FU to Treat Facial Actinic Keratosis	https://ClinicalTrials.gov/show/NCT02242747	Completed	University of Sao Paulo	2014-07-31
NCT02239679	Controlled Study of the Occurrence of Actinic Keratosis on the Face After Cryotherapy + Aminolevulinic Acid (ALA) Photodynamic Therapy	https://ClinicalTrials.gov/show/NCT02239679	Completed	DUSA Pharmaceuticals, Inc.	2016-07-31
NCT02160626	Dose-Response Profile of A-101 in Subjects With Seborrheic Keratosis	https://ClinicalTrials.gov/show/NCT02160626	Completed	Aclaris Therapeutics, Inc.	2014-12-31
NCT02149342	Daylight-mediated Photodynamic Therapy of Actinic Keratoses:Comparing 0.2%HAL With 16%MAL	https://ClinicalTrials.gov/show/NCT02149342	Completed	Joint Authority for Päijät-Häme Social and Health Care	2015-09-30
NCT02137785	Safety and Efficacy Study of Photodynamic Therapy With Levulan Kerastick + Blue Light for Actinic Keratoses on the Upper Extremities	https://ClinicalTrials.gov/show/NCT02137785	Completed	DUSA Pharmaceuticals, Inc.	2015-03-31
NCT02126670	ACT01 in Combination With Comp01-04 in Patients With Actinic Keratosis	https://ClinicalTrials.gov/show/NCT02126670	Completed	Promius Pharma, LLC	2014-09-30
NCT02124239	Pharmacokinetics of Ingenol Mebutate Gel in Actinic Keratosis Under Maximum Use Conditions	https://ClinicalTrials.gov/show/NCT02124239	Completed	LEO Pharma	2014-11-30
NCT02120898	A Study to Evaluate the Safety and Efficacy Imiquimod Cream, 2.5% in Participants With Actinic Keratoses	https://ClinicalTrials.gov/show/NCT02120898	Completed	Actavis Inc.	2014-04-30
NCT02120456	Safety and Efficacy of Escalating Doses of LEO 43204 Applied Once Daily for Two Consecutive Days on Approximately 250 cm2 on Trunk and Extremities in Subjects With Actinic Keratosis	https://ClinicalTrials.gov/show/NCT02120456	Completed	LEO Pharma	2015-05-31
NCT02085395	Clinical Study Assessment of SR-T100 Topical Gel Against Actinic Keratosis	https://ClinicalTrials.gov/show/NCT02085395	Completed	G&E Herbal Biotechnology Co., LTD	2010-04-30
NCT02062853	Continuous Quality Improvement (CQI) Pilot Study Evaluating the Utility of an Educational Video	https://ClinicalTrials.gov/show/NCT02062853	Completed	University of California, Davis	2016-06-30
NCT01302925	PEP005 Gel - Evaluation of Local Tolerability After Exposure to Ingenol Mebutate Gel Followed by Hand Washing in Healthy Subjects	https://ClinicalTrials.gov/show/NCT01302925	Completed	Peplin	2011-03-31
NCT01281644	Treatment of Keratosis Pilaris With 810 nm Diode Laser	https://ClinicalTrials.gov/show/NCT01281644	Completed	Northwestern University	2011-10-31
NCT02029066	Pharmacokinetic Study of Solamargine in Patients With Actinic Keratosis	https://ClinicalTrials.gov/show/NCT02029066	Completed	G&E Herbal Biotechnology Co., LTD	2014-02-28
NCT02019355	Actinic Keratosis Study	https://ClinicalTrials.gov/show/NCT02019355	Completed	Washington University School of Medicine	2015-03-31
NCT01998984	Efficacy and Safety of Ingenol Mebutate Gel 0.06% When Applied Once Daily for 2, 3 or 4 Consecutive Days to a Treatment Area of Approximately 250 cm2 on Trunk and Extremities in Subjects With Actinic Keratosis	https://ClinicalTrials.gov/show/NCT01998984	Completed	LEO Pharma	2014-07-31
NCT01986920	Study of Safety, Tolerability and Effectiveness of A-101 in Subjects With Seborrheic Keratosis	https://ClinicalTrials.gov/show/NCT01986920	Completed	Aclaris Therapeutics, Inc.	2014-02-25
NCT01966120	Safety and Efficacy Study for the Field-directed Treatment of Actinic Keratosis (AK) With Photodynamic Therapy (PDT)	https://ClinicalTrials.gov/show/NCT01966120	Completed	Biofrontera Bioscience GmbH	2014-09-30
NCT01962987	A Study Comparing Diclofenac Sodium Gel 3% to Solaraze® (Diclofenac Sodium) Gel 3% in the Treatment of Actinic Keratosis	https://ClinicalTrials.gov/show/NCT01962987	Completed	Actavis Inc.	2013-09-30
NCT01935531	Effects of Topical Diclofenac on Tumor Metabolism	https://ClinicalTrials.gov/show/NCT01935531	Completed	University Hospital Regensburg	2016-01-31
NCT01922050	A Study of Increasing Strengths, Safety and Efficacy of Two Formulas of LEO 43204 on the Face or the Chest in Patients With Actinic Keratosis	https://ClinicalTrials.gov/show/NCT01922050	Completed	LEO Pharma	2014-11-30
NCT01921907	Evaluation of a Topical Treatment for Actinic Keratosis	https://ClinicalTrials.gov/show/NCT01921907	Completed	Assuta Hospital Systems	2014-06-30
NCT01905891	Nanocytology Test to Evaluate Skin Cancer in High Risk Patients	https://ClinicalTrials.gov/show/NCT01905891	Completed	Northwestern University	2014-11-30
NCT01898936	Fractional Laser-assisted Daylight Photodynamic Therapy Versus Daylight Photodynamic for Treatment of Actinic Keratoses	https://ClinicalTrials.gov/show/NCT01898936	Completed	Oslo University Hospital	2016-09-30
NCT04319159	Study to Evaluate the Safety of BF-200 ALA (Ameluz®) for Photodynamic Therapy (PDT) in the Treatment of Expanded Fields of Actinic Keratosis (AK)	https://ClinicalTrials.gov/show/NCT04319159	Recruiting	Biofrontera Bioscience GmbH	2020-09-30
NCT01892137	Histological Confirmation of Clinical Clearance of Actinic Keratoses Following Treatment With Ingenol Mebutate Gel, 0.05%	https://ClinicalTrials.gov/show/NCT01892137	Completed	LEO Pharma	2014-03-31
NCT01836367	Ingenol Mebutate 0.015% Gel in the Treatment of Actinic Keratoses (AK) on the Face and Scalp	https://ClinicalTrials.gov/show/NCT01836367	Completed	Icahn School of Medicine at Mount Sinai	2013-08-31
NCT01821391	Phase 3b Study of Metvix NDL-PDT Versus Metvix c-PDT in Subjects With Actinic Keratoses	https://ClinicalTrials.gov/show/NCT01821391	Completed	Galderma	2014-01-31
NCT01820260	Safety and Efficacy of Doses of Ingenol Mebutate Once Daily for Two or Three Consecutive Days in Subjects With Actinic Keratosis	https://ClinicalTrials.gov/show/NCT01820260	Completed	LEO Pharma	2014-08-31
NCT01812837	The Use of Microneedles in Photodynamic Therapy	https://ClinicalTrials.gov/show/NCT01812837	Completed	University of California, Davis	2014-03-31
NCT01803477	Safety and Dose Finding Study of New Vehicle Formulations Containing Ingenol Mebutate to Treat Actinic Keratosis on the Forearm	https://ClinicalTrials.gov/show/NCT01803477	Completed	LEO Pharma	2013-10-31
NCT01787383	A Simultaneous Treatment Regimen Compared to a Sequential Treatment Regimen With Ingenol Mebutate Gel 0.015% and 0.05% of Two Areas With Actinic Keratosis on Face/Scalp and Trunk/Extremities	https://ClinicalTrials.gov/show/NCT01787383	Completed	LEO Pharma	2014-01-31
NCT01757613	Study Whose Purpose is to Find an Optimal Dose for the Treatment With AK 3012 in Patients With Actinic Keratosis	https://ClinicalTrials.gov/show/NCT01757613	Completed	Dolorgiet GmbH & Co. KG	2014-01-31
NCT01752972	Effect of Spirulina on Zinc, Vitamin E and Linoleic Acid Levels in Palm Skin Following Chronic Exposure to Arsenic	https://ClinicalTrials.gov/show/NCT01752972	Completed	Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh	2011-12-31
NCT01748669	Effectiveness of Garlic Oil in the Treatment of Arsenical Palmer Keratosis	https://ClinicalTrials.gov/show/NCT01748669	Completed	Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh	2012-07-31
NCT01742663	A Study Comparing Diclofenac Sodium Gel 3% to Solaraze® Gel 3% in the Treatment of Actinic Keratosis	https://ClinicalTrials.gov/show/NCT01742663	Completed	Taro Pharmaceuticals USA	2013-07-31
NCT01735097	Effect of Nigella Sativa in the Treatment of Palmer Arsenical Keratosis	https://ClinicalTrials.gov/show/NCT01735097	Completed	Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh	2013-11-30
NCT01731756	Effects of Leaf Extract of Azadirachta Indica in Palmer Arsenical Keratosis	https://ClinicalTrials.gov/show/NCT01731756	Completed	Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh	2013-12-31
NCT01703078	Safety and Tolerability of Different Concentrations of an Ingenol Derivative Field Therapy in the Treatment of Actinic Keratosis	https://ClinicalTrials.gov/show/NCT01703078	Completed	LEO Pharma	2013-03-31
NCT01686152	Study Comparing Imiquimod Cream, 3.75% to Zyclara® (Imiquimod) Cream, 3.75% in the Treatment of Actinic Keratosis	https://ClinicalTrials.gov/show/NCT01686152	Completed	Teva Pharmaceuticals USA	2013-08-31
NCT01600014	Ingenol Mebutate Gel, 0.015% Repeat Use for Multiple Actinic Keratoses on Face and Scalp	https://ClinicalTrials.gov/show/NCT01600014	Completed	LEO Pharma	2014-02-28
NCT01583816	Dose-finding, Safety, Efficacy Trial of Topical Resiquimod in Patients With Multiple Actinic Keratosis Lesions	https://ClinicalTrials.gov/show/NCT01583816	Completed	Spirig Pharma Ltd.	2013-11-30
NCT03327831	Study of Daylight Photodynamic Therapy With Aminolevulinic Acid for Actinic Keratoses	https://ClinicalTrials.gov/show/NCT03327831	Completed	University of California, Irvine	2017-02-28
NCT01541553	A Sequential Treatment Regimen of Cryotherapy and Picato® for the Treatment of Actinic Keratosis on the Face and Scalp	https://ClinicalTrials.gov/show/NCT01541553	Completed	LEO Pharma	2013-07-31
NCT01516515	Efficacy and Safety Phase II Study of SR-T100 to Treat Actinic Keratosis	https://ClinicalTrials.gov/show/NCT01516515	Completed	G&E Herbal Biotechnology Co., LTD	2017-12-31
NCT01502020	A Bioequivalence Study With Clinical Endpoints Comparing Generic Imiquimod Cream, 3.75% and Zyclaraâ„¢ (Imiquimod) Cream, 3.75% in Subjects With Actinic Keratoses	https://ClinicalTrials.gov/show/NCT01502020	Completed	Actavis Mid-Atlantic LLC	2011-08-31
NCT01493921	Efficacy Study & Safety Evaluation of SR-T100 Gel in Actinic Keratosis Treatment	https://ClinicalTrials.gov/show/NCT01493921	Completed	G&E Herbal Biotechnology Co., LTD	2015-11-30
NCT01475955	Short-incubation Levulan Photodynamic Therapy Versus Vehicle for Face/Scalp Actinic Keratosis (AK)	https://ClinicalTrials.gov/show/NCT01475955	Completed	DUSA Pharmaceuticals, Inc.	2012-11-30
NCT01475071	Intra-individual Comparison of Efficacy and Safety of Metvix® Natural Daylight Photodynamic Therapy Versus Conventional Metvix® Photodynamic Therapy in Subject With Mild Actinic Keratoses	https://ClinicalTrials.gov/show/NCT01475071	Completed	Galderma	2012-11-30
NCT01459393	Comparison Between 5-aminolevulinic Acid Photodynamic Therapy Versus Cryotherapy for Actinic Keratosis Treatment	https://ClinicalTrials.gov/show/NCT01459393	Completed	Barretos Cancer Hospital	2011-11-30
NCT01458587	Levulan PDT Versus Vehicle for Extremity Actinic Keratoses (AK)	https://ClinicalTrials.gov/show/NCT01458587	Completed	DUSA Pharmaceuticals, Inc.	2012-07-31
NCT01453179	Long-term Effects of Imiquimod and Diclofenac in Actinic Keratoses (LEIDA 2)	https://ClinicalTrials.gov/show/NCT01453179	Completed	MEDA Pharma GmbH & Co. KG	2015-03-31
NCT01449513	PEP005 Gel - Biological Effects in Actinic Keratosis Assessed by Reflectance Confocal Microscopy	https://ClinicalTrials.gov/show/NCT01449513	Completed	LEO Pharma	2012-05-31
NCT01444989	Development and Validation of a Quality of Life Instrument for Actinic Keratosis	https://ClinicalTrials.gov/show/NCT01444989	Completed	Wake Forest University Health Sciences	2011-12-31
NCT01442727	Selenium in the Treatment of Arsenic Toxicity and Cancers	https://ClinicalTrials.gov/show/NCT01442727	Completed	Texas Tech University	2009-04-30
NCT01387711	PEP005 Gel - Biological Effects in Actinic Keratosis Assessed by Histology	https://ClinicalTrials.gov/show/NCT01387711	Completed	LEO Pharma	2012-06-30
NCT01358851	LAS41005 in Hyperkeratotic Actinic Keratosis	https://ClinicalTrials.gov/show/NCT01358851	Completed	Almirall, S.A.	2012-03-31
NCT01354717	Bioequivalence Study of Generic Fluorouracil 0.5% Cream and 0.5% Carac® and Placebo	https://ClinicalTrials.gov/show/NCT01354717	Completed	Spear Pharmaceuticals	2011-03-31
NCT04336514	A Longitudinal Quantitative Assessment of the Effectiveness of Metatarsal Pads on Plantar Pressures	https://ClinicalTrials.gov/show/NCT04336514	Active, not recruiting	University Health Network, Toronto	2021-05-31
NCT04269395	A Study to Assess Recurrence of Actinic Keratosis in Participants Treated With Methyl Aminolevulinate Hydrochloride Cream or Vehicle Cream Who Achieved Complete Response to Treated Lesions in Earlier Study	https://ClinicalTrials.gov/show/NCT04269395	Recruiting	Galderma R&D	2020-06-30
NCT04249115	Nano-Pulse Stimulation (NPS) in Seborrheic Keratosis Optimization Study	https://ClinicalTrials.gov/show/NCT04249115	Active, not recruiting	Pulse Biosciences, Inc.	2020-02-29
NCT04229277	Fast Track Diagnosis of Skin Cancer by Advanced Imaging	https://ClinicalTrials.gov/show/NCT04229277	Active, not recruiting	University Hospital Bispebjerg and Frederiksberg	2020-03-22
NCT04085367	Multicenter Study to Assess the Efficacy and Safety of Methyl Aminolevulinate Hydrochloride (MAL) 16.8% Cream (CD06809-41) Versus Vehicle Cream for Actinic Keratosis of the Face	https://ClinicalTrials.gov/show/NCT04085367	Recruiting	Galderma R&D	2020-10-06
NCT03963102	Duration of Ameluz Application in Acral Actinic Keratoses Response	https://ClinicalTrials.gov/show/NCT03963102	Recruiting	Royal Cornwall Hospitals Trust	2020-10-01
NCT03914417	Genomic Markers Before and After Treatment of Actinic Keratosis With Imiquimod 3.75% Cream	https://ClinicalTrials.gov/show/NCT03914417	Completed	Icahn School of Medicine at Mount Sinai	2016-06-30
NCT03906253	Effectiveness of Fractionated Laser Resurfacing to Protect Geriatric Skin From Actinic Neoplasia	https://ClinicalTrials.gov/show/NCT03906253	Recruiting	Wright State Physicians	2025-12-31
NCT03846531	Nano-Pulse Stimulation (NPS) in Seborrheic Keratosis Study	https://ClinicalTrials.gov/show/NCT03846531	Completed	Pulse Biosciences, Inc.	2017-11-13
NCT03805737	Indoor Daylight Photo Dynamic Therapy for Actinic Keratosis	https://ClinicalTrials.gov/show/NCT03805737	Recruiting	Dartmouth-Hitchcock Medical Center	2020-11-30
NCT03731988	Efficacy of Ablative Fractional Laser-assisted Photodynamic Therapy According to the Laser Density for Actinic Keratosis	https://ClinicalTrials.gov/show/NCT03731988	Completed	Dong-A University	2017-10-30
NCT03727074	Bioequivalence Study to Compare Sol-Gel Technologies’ 5-FU Cream With Efudex® (5-FU) Cream	https://ClinicalTrials.gov/show/NCT03727074	Completed	Sol-Gel Technologies, Ltd.	2019-12-19
NCT03697590	Photodynamic Therapy of Actinic Keratosis of the Face and Scalp With and Without Prior Curettage	https://ClinicalTrials.gov/show/NCT03697590	Completed	Bispebjerg Hospital	2017-12-20
NCT03643744	Photodynamic Therapy-Induced Immune Modulation: Part III	https://ClinicalTrials.gov/show/NCT03643744	Recruiting	Wright State Physicians	2021-03-31
NCT03642535	Aminolevulinic Acid-photodynamic Therapy for Facial Actinic Keratosis Treatment and Prevention	https://ClinicalTrials.gov/show/NCT03642535	Recruiting	Shanghai Dermatology Hospital	2025-06-01
NCT03635853	Identification of Compound Isolated From Cock’s Comb and Its Effect on Arsenical Palmar Keratosis	https://ClinicalTrials.gov/show/NCT03635853	Recruiting	Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh	2018-12-31
NCT03632733	Effects of Antimicrobials on the Altered Skin Flora in Arsenical Keratosis	https://ClinicalTrials.gov/show/NCT03632733	Recruiting	Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh	2018-10-30
NCT03606122	5-ALA Patch-PDT of Actinic Keratosis on the Upper Extremities	https://ClinicalTrials.gov/show/NCT03606122	Completed	photonamic GmbH & Co. KG	2019-07-16
NCT03596619	The Study of Plum-blossom Needling Enhancing Efficacy of Aminolevulinic Acid-photodynamic Therapy for Actinic Keratosis	https://ClinicalTrials.gov/show/NCT03596619	Recruiting	Shanghai Dermatology Hospital	2021-12-30
NCT03575780	Single-Center Study Evaluating Systemic Exposure and Safety of KX2-391 Ointment 1% on the Face or Balding Scalp in Subjects With Actinic Keratosis	https://ClinicalTrials.gov/show/NCT03575780	Completed	Athenex, Inc.	2019-04-25
NCT03511326	PRO With Luxerm® in the Field Treatment of Thin and Non-hyperkeratotic Non-pigmented AK	https://ClinicalTrials.gov/show/NCT03511326	Completed	Galderma	2017-11-28
NCT03508856	Clinical and Histologic Evaluation of Picato 0.15% Gel in the Cosmetic Improvement of Photoaged Skin	https://ClinicalTrials.gov/show/NCT03508856	Completed	Skin Laser & Surgery Specialists	2016-08-09
NCT03487588	An A Study Assessing Subject Satisfaction With A-101 Topical Solution for Seborrheic Keratoses	https://ClinicalTrials.gov/show/NCT03487588	Completed	Aclaris Therapeutics, Inc.	2018-11-14
NCT03483935	Microwave Therapy for Treatment of Precancerous Actinic Keratoses	https://ClinicalTrials.gov/show/NCT03483935	Completed	University of Dundee	2019-02-28
NCT03447925	Treatment of Plantar Keratosis With Medicinal Plant in Diabetic Patients	https://ClinicalTrials.gov/show/NCT03447925	Recruiting	Universidade do Vale do Sapucai	2019-10-01
NCT01265602	Double-blind, Randomized, Vehicle- and Comparator-controlled, Multi-center Trial to Evaluate the Efficacy and Safety of LAS41007 in the Treatment of Actinic Keratosis	https://ClinicalTrials.gov/show/NCT01265602	Completed	Almirall, S.A.	2012-03-31
NCT01260987	Fractional CO2 Laser Assisted Photodynamic Therapy	https://ClinicalTrials.gov/show/NCT01260987	Completed	Bispebjerg Hospital	2012-08-31
NCT01214564	Study to Evaluate the Safety and Efficacy of PEP005(Ingenol Mebutate) Gel, 0.05%, in Patients With Seborrhoeic Keratosis	https://ClinicalTrials.gov/show/NCT01214564	Completed	Peplin	2010-12-31
NCT01159860	Is Cryosurgery or Curettage More Effective at Treating Seborrheic Keratoses?	https://ClinicalTrials.gov/show/NCT01159860	Completed	Milton S. Hershey Medical Center	2012-05-11
NCT01053000	Photodynamic Therapy With Levulan® +/- Topical Retinoid Pre-Treatment In The Treatment Of Actinic Keratoses	https://ClinicalTrials.gov/show/NCT01053000	Completed	Stewart, Roger H., M.D., P.A.	2010-11-30
NCT01000636	Gene Expression in Renal Transplant Patients With Field Actinic Keratosis Undergoing Metvix® Photodynamic Therapy (PDT)	https://ClinicalTrials.gov/show/NCT01000636	Completed	Galderma	2011-10-31
NCT00991861	Efficacy and Safety Study of LAS41007 in the Treatment of Actinic Keratosis	https://ClinicalTrials.gov/show/NCT00991861	Completed	Almirall, S.A.	2010-02-28
NCT00987246	Study on the Efficacy of LAS41005 in the Treatment of Actinic Keratosis	https://ClinicalTrials.gov/show/NCT00987246	Completed	Almirall, S.A.	2009-06-30
NCT00948428	Bioequivalence of Generic Imiquimod Cream, 5% When Compared to Aldaraâ„¢ (Imiquimod) Cream, 5% in the Treatment of Actinic Keratosis	https://ClinicalTrials.gov/show/NCT00948428	Completed	Actavis Inc.	2009-03-31
NCT00942604	A Multicenter Study to Evaluate the Efficacy and Safety of PEP005 (Ingenol Mebutate) Gel When Used to Treat Actinic Keratoses (AKs) on the Non Head Locations	https://ClinicalTrials.gov/show/NCT00942604	Completed	Peplin	2009-10-31
NCT00926952	Short Incubation Methylaminolevulinate Photodynamic Therapy Without Occlusion	https://ClinicalTrials.gov/show/NCT00926952	Completed	Innovaderm Research Inc.	2010-12-31
NCT00917306	A Multi-center Study to Evaluate the Safety and Efficacy of PEP005 (Ingenol Mebutate) Gel, When Used to Treat Actinic Keratoses on Non-head Locations (Trunk and Extremities)	https://ClinicalTrials.gov/show/NCT00917306	Completed	Peplin	2009-09-30
NCT00916006	A Multi-center Study to Evaluate the Efficacy and Safety of PEP005 (Ingenol Mebutate) Gel, When Used to Treat Actinic Keratoses on the Head (Face or Scalp)	https://ClinicalTrials.gov/show/NCT00916006	Completed	Peplin	2009-09-30
NCT00915551	A Multi-Center Study to Evaluate the Efficacy and Safety of PEP005 (Ingenol Mebutate) Gel, When Used to Treat Actinic Keratoses on the Head (Face or Scalp)	https://ClinicalTrials.gov/show/NCT00915551	Completed	Peplin	2009-09-30
NCT00894647	Safety and Effectiveness Study of Actinic Keratosis Treatment Following Cryosurgery	https://ClinicalTrials.gov/show/NCT00894647	Completed	Graceway Pharmaceuticals, LLC	2010-02-28
NCT00859105	A Randomized, Double-Blind, Parallel-Group, Vehicle-Controlled Therapeutic Equivalence Study of Three Imiquimod Cream 5% Treatments for Patients With Actinic Keratosis	https://ClinicalTrials.gov/show/NCT00859105	Completed	Apotex Inc.	2008-11-30
NCT00852137	A Study to Evaluate the Pharmacokinetics of PEP005 (Ingenol Mebutate) Gel, 0.05%, When Applied in a Maximal Use Setting to the Dorsal Aspect of the Forearm in Patients With Actinic Keratosis	https://ClinicalTrials.gov/show/NCT00852137	Completed	Peplin	2009-06-30
NCT00850811	A Study to Evaluate the Photoirritation Potential of PEP005 (Ingenol Mebutate) Gel, 0.01% in Healthy Volunteers	https://ClinicalTrials.gov/show/NCT00850811	Completed	Peplin	2009-04-30
NCT00850681	A Study to Evaluate the Photoallergic Potential of PEP005 (Ingenol Mebutate) Gel, 0.01% in Healthy Volunteers	https://ClinicalTrials.gov/show/NCT00850681	Completed	Peplin	2009-04-30
NCT00843323	Photodynamic Therapy (PDT) Effect on Large Surface Photodamaged Skin	https://ClinicalTrials.gov/show/NCT00843323	Completed	University of Sao Paulo	2009-03-31
NCT03083470	Study of SOR007 Ointment for Actinic Keratosis	https://ClinicalTrials.gov/show/NCT03083470	Completed	DFB Soria, LLC	2018-03-12
NCT00828568	Bioequivalence Study of Two Imiquimod Cream 5%	https://ClinicalTrials.gov/show/NCT00828568	Completed	Taro Pharmaceuticals USA	2009-03-31
NCT03279328	Evaluating Skin Appearance Following 5-Flourouracil Cream for Treatment of Actinic Keratosis and the Effects of Topical Agents	https://ClinicalTrials.gov/show/NCT03279328	Completed	University of Arizona	2018-07-31
NCT01788007	Clinical Study to Evaluate the Bioequivalence of Two Imiquimod Cream 3.75% Formulations in Patients With Actinic Keratosis.	https://ClinicalTrials.gov/show/NCT01788007	Completed	Taro Pharmaceuticals USA	2013-10-31
NCT01611480	Efficacy and Safety of a New Topical Formulation With Imiquimod (Limtop) Applied 1, 3 or 7 Times Weekly During 2 x 2 Weeks Treatment for Actinic Keratosis on the Head	https://ClinicalTrials.gov/show/NCT01611480	Completed	Moberg Pharma AB	2013-01-31
NCT01926496	Risk of Squamous Cell Carcinoma on Skin Areas Treated With Ingenol Mebutate Gel, 0.015% and Imiquimod Cream, 5%	https://ClinicalTrials.gov/show/NCT01926496	Completed	LEO Pharma	2019-07-11
NCT01893203	Daylight-PDT for AKs: Comparing Two Photosensitizers (BF-200 ALA and MAL)	https://ClinicalTrials.gov/show/NCT01893203	Completed	Joint Authority for Päijät-Häme Social and Health Care	2014-12-31
NCT01541228	Photodynamic Treatment of Actinic Keratoses With Different Light Doses	https://ClinicalTrials.gov/show/NCT01541228	Completed	Lithuanian University of Health Sciences	2011-04-30
NCT04140292	Vitamin D Supplementation as a Neoadjuvant for Photodynamic Therapy of Actinic Keratoses	https://ClinicalTrials.gov/show/NCT04140292	Recruiting	Case Comprehensive Cancer Center	2021-12-31
NCT04396184	Conventional Photodynamic Therapy vs. Painless Photodynamic Therapy for Actinic Keratosis	https://ClinicalTrials.gov/show/NCT04396184	Recruiting	Shanghai Dermatology Hospital	2021-04-30
NCT03148691	A Randomized, Vehicle-Controlled Study of 2 Concentrations of A-101 for the Treatment of Seborrheic Keratosis	https://ClinicalTrials.gov/show/NCT03148691	Completed	Aclaris Therapeutics, Inc.	2018-02-28
NCT02644187	Pain Relief During Photodynamic Therapy for Actinic Keratoses With a New Irradiation Protocol	https://ClinicalTrials.gov/show/NCT02644187	Completed	Vastra Gotaland Region	2017-03-31
NCT02406014	Efficacy and Safety of Ingenol Mebutate Gel 0.015% Compared to Diclofenac Sodium Gel 3% in Subjects With Actinic Keratoses on the Face or Scalp	https://ClinicalTrials.gov/show/NCT02406014	Completed	LEO Pharma	2016-06-30
NCT02100813	Safety and Efficacy of Doses of LEO 43204 Once Daily for Two Consecutive Days on Full Balding Scalp in Subjects With Actinic Keratosis	https://ClinicalTrials.gov/show/NCT02100813	Completed	LEO Pharma	2015-03-31
NCT03210740	Safety and Efficacy Study of AM001 Cream in the Treatment of Actinic Keratosis	https://ClinicalTrials.gov/show/NCT03210740	Completed	AmDerma	2018-02-13
NCT00786994	The Efficacy and Tolerability of Oleogel-S-10 in Patients With Actinic Keratoses	https://ClinicalTrials.gov/show/NCT00786994	Completed	Amryt Pharma	2010-11-30
NCT00777127	Long-term Effects of Imiquimod and Diclofenac in Actinic Keratoses	https://ClinicalTrials.gov/show/NCT00777127	Completed	MEDA Pharma GmbH & Co. KG	2012-11-30
NCT00774787	Topical Imiquimod Cream in Combination With Cryotherapy for the Treatment of Actinic Keratoses	https://ClinicalTrials.gov/show/NCT00774787	Completed	Rigel Dermatology	2010-03-31
NCT00742391	A Multicenter Study to Evaluate the Efficacy and Safety of PEP005 (Ingenol Mebutate) Gel When Used to Treat Actinic Keratoses (AKs) on the Non Head Locations	https://ClinicalTrials.gov/show/NCT00742391	Completed	Peplin	2009-02-28
NCT00711178	A Randomized Multicenter Study of Daylight Mediated Photodynamic Therapy (PDT)	https://ClinicalTrials.gov/show/NCT00711178	Completed	Bispebjerg Hospital	2009-01-31
NCT00710203	Dermatosis Papulosa Nigra	https://ClinicalTrials.gov/show/NCT00710203	Completed	University of California, Davis	2009-12-31
NCT00700063	A Multicenter Study to Evaluate the Safety and Efficacy of PEP005 Topical Gel When Used to Treat Actinic Keratoses on the Head (Face or Scalp)	https://ClinicalTrials.gov/show/NCT00700063	Completed	Peplin	2008-10-31
NCT00696488	Measuring Adherence To Topical 5-Fluorouracil in a Clinic Population	https://ClinicalTrials.gov/show/NCT00696488	Completed	Wake Forest University Health Sciences	2007-08-31
NCT00695578	Clinical Trial to Evaluate Biafine Cream Versus Standard Care in Subjects With Actinic Keratosis Post Cryotherapy	https://ClinicalTrials.gov/show/NCT00695578	Completed	Wake Forest University Health Sciences	2007-06-30
NCT00659893	Safety and Toleration of PEP005 Topical Gel When Applied to a Treatment Area of up to 100cm2	https://ClinicalTrials.gov/show/NCT00659893	Completed	Peplin	2008-11-30
NCT00605176	Safety and Effectiveness Study of Imiquimod Creams for Treatment of Actinic Keratoses (AKs)	https://ClinicalTrials.gov/show/NCT00605176	Completed	Graceway Pharmaceuticals, LLC	2008-07-31
NCT00603798	Safety and Effectiveness Study of Imiquimod Creams for the Treatment of Actinic Keratoses (AKs)	https://ClinicalTrials.gov/show/NCT00603798	Completed	Graceway Pharmaceuticals, LLC	2008-07-31
NCT00558688	A Photodynamic Therapy for Treatment of Actinic Keratoses	https://ClinicalTrials.gov/show/NCT00558688	Completed	Northwestern University	2009-08-31
NCT00544297	A Study to Examine the Safety and Toleration of PEP005 Topical Gel in Patients With Actinic Keratoses on the Top of the Hand	https://ClinicalTrials.gov/show/NCT00544297	Completed	Peplin	2008-01-31
NCT00544258	Pharmacokinetic Study to Evaluate the Extent of Systemic Absorption of PEP005	https://ClinicalTrials.gov/show/NCT00544258	Completed	Peplin	2008-05-31
NCT00472459	PDT With Metvix® 160 mg/g Cream in Organ Transplant Recipients With Non-melanoma Skin Cancer	https://ClinicalTrials.gov/show/NCT00472459	Completed	Galderma	NA
NCT00432224	Treatment of Actinic Keratoses With Photodynamic Therapy Using Sunlight Versus Red Light	https://ClinicalTrials.gov/show/NCT00432224	Completed	Bispebjerg Hospital	NA
NCT00427050	A Study to Determine the Optimal Tolerated Regime and Safety of PEP005 Topical Gel	https://ClinicalTrials.gov/show/NCT00427050	Completed	Peplin	2007-11-30
NCT00377273	An Open-Label 18-Month Safety Study of Fluorouracil Cream 0.5% for the Treatment of Actinic Keratoses	https://ClinicalTrials.gov/show/NCT00377273	Completed	Sanofi	NA
NCT00375739	Study to Determine the Safety of PEP005 0.025% and 0.05% Topical Gel in Patients With Actinic Keratoses	https://ClinicalTrials.gov/show/NCT00375739	Completed	Peplin	2007-06-30
NCT00335179	Cellular and Molecular Events During Treatment of Actinic Keratosis With Imiquimod 5% Cream	https://ClinicalTrials.gov/show/NCT00335179	Completed	Graceway Pharmaceuticals, LLC	2003-07-31
NCT00308867	PD P 506 A-PDT Versus Placebo-PDT and Cryosurgery for the Treatment of AK	https://ClinicalTrials.gov/show/NCT00308867	Completed	photonamic GmbH & Co. KG	2007-06-30
NCT00308854	Photodynamic Therapy With PD P 506 A Compared With Placebo-PDT for the Treatment of AK	https://ClinicalTrials.gov/show/NCT00308854	Completed	photonamic GmbH & Co. KG	2007-08-31
NCT00306800	Metvix PDT Versus Vehicle PDT With Aktilite CL128 Lamp in Patients With Actinic Keratosis on the Face and Scalp	https://ClinicalTrials.gov/show/NCT00306800	Completed	Galderma	NA
NCT00304239	Metvix PDT Versus Vehicle PDT With Aktilite CL128 Lamp in Patients With Actinic Keratosis on the Face and Scalp	https://ClinicalTrials.gov/show/NCT00304239	Completed	Galderma	NA
NCT00294320	Evaluation of Two Different Non-Invasive Techniques to Monitor the Clearance of Actinic Keratosis Lesions	https://ClinicalTrials.gov/show/NCT00294320	Completed	MEDA Pharma GmbH & Co. KG	2007-01-31
NCT00269074	Effect of IDEA-070 on Pain and Inflammation Induced by PDT	https://ClinicalTrials.gov/show/NCT00269074	Completed	IDEA AG	NA
NCT00239135	Study to Determine the Maximum Tolerated Dose and Safety of PEP005 Topical Gel	https://ClinicalTrials.gov/show/NCT00239135	Completed	Peplin	2005-12-31
NCT00204542	Comparison of the Efficacy and Tolerability of Solaraze for 3 Versus 6 Months in Patients With Mild to Moderate Actinic Keratosis Located on the Face and Head	https://ClinicalTrials.gov/show/NCT00204542	Completed	University Hospital Tuebingen	2009-03-31
NCT00189267	A Study to Evaluate the Effectiveness and Safety of Multiple Applications of Imiquimod 5% Cream for the Treatment of Actinic Keratoses in Organ Transplant Recipients	https://ClinicalTrials.gov/show/NCT00189267	Completed	MEDA Pharma GmbH & Co. KG	NA
NCT00175643	Safety and Efficacy of Imiquimod Applied in Dose-Cycle for Actinic Keratoses	https://ClinicalTrials.gov/show/NCT00175643	Completed	University of British Columbia	NA
NCT00121511	The Effect of Efudex Treatment on Photoaged Skin	https://ClinicalTrials.gov/show/NCT00121511	Completed	University of Michigan	NA
NCT00116649	Open-Label Safety Study to Evaluate Imiquimod Cream, 5% for Large Areas of Actinic Keratosis	https://ClinicalTrials.gov/show/NCT00116649	Completed	Graceway Pharmaceuticals, LLC	2007-05-31
NCT00115154	Study to Assess the Safety and Efficacy of Imiquimod 5% Cream for the Treatment of Actinic Keratosis on the Arms and Hands	https://ClinicalTrials.gov/show/NCT00115154	Completed	Graceway Pharmaceuticals, LLC	NA
NCT00110682	Study of Imiquimod 5% Cream in Addition to Cryotherapy in the Management of Actinic Keratoses	https://ClinicalTrials.gov/show/NCT00110682	Completed	Derm Research @ 888 Inc.	2006-10-31
NCT00107965	Study to Determine the Safety of Two Applications of PEP005 Topical Gel to Actinic Keratoses	https://ClinicalTrials.gov/show/NCT00107965	Completed	Peplin	2005-09-30
NCT00089180	T4N5 Liposomal Lotion in Preventing The Recurrence of Nonmelanoma Skin Cancer in Patients Who Have Undergone a Kidney Transplant	https://ClinicalTrials.gov/show/NCT00089180	Completed	National Cancer Institute (NCI)	2007-01-31
NCT00021294	Eflornithine With or Without Triamcinolone in Preventing Nonmelanoma Skin Cancer in Patients With Actinic Keratosis	https://ClinicalTrials.gov/show/NCT00021294	Completed	University of Arizona	2002-06-30

Observational Studiess

#If less then 500 studies

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT02674048	Metvix Daylight PDT in Actinic Keratosis	https://ClinicalTrials.gov/show/NCT02674048	Completed	Galderma	2016-10-31
NCT02594436	The Use of Picato® (Ingenol Mebutate) to Treat Actinic Keratosis in Standard Clinical Practice	https://ClinicalTrials.gov/show/NCT02594436	Completed	LEO Pharma	2017-11-30
NCT02421471	PMS to Evaluate the Safety and Efficacy of Picato® Gel	https://ClinicalTrials.gov/show/NCT02421471	Completed	LEO Pharma	2018-01-19
NCT02362152	The Real Life Topical Field Treatment of Actinic Keratosis Study	https://ClinicalTrials.gov/show/NCT02362152	Completed	LEO Pharma	2015-12-31
NCT02209012	Twelve Month Follow-Up of CP0108	https://ClinicalTrials.gov/show/NCT02209012	Completed	DUSA Pharmaceuticals, Inc.	2016-02-29
NCT02090465	Assessment of Treatment Success and Quality of Life in Patients With Actinic Keratoses Under Therapy With Ingenol Mebutate in a Period of 8 Weeks	https://ClinicalTrials.gov/show/NCT02090465	Completed	LEO Pharma	2013-12-31
NCT01571336	Photodynamic Therapy of Actinic Keratoses With Alacare®	https://ClinicalTrials.gov/show/NCT01571336	Completed	photonamic GmbH & Co. KG	2016-05-31
NCT04267419	Malondialdehyde and Nitrous Oxide as Salivary Biomarkers for Different Oral Lesions	https://ClinicalTrials.gov/show/NCT04267419	Completed	Beni-Suef University	2019-12-15
NCT04202445	TreatMent of ActInic KerAtosis Lesions : pharmacoepiDemiological Study of the Impact in Real Life of ingenOl Mebutate Gel (Picato®) on Patients Satisfaction	https://ClinicalTrials.gov/show/NCT04202445	Completed	LEO Pharma	2016-02-29
NCT04024579	Treatment of Actinic Keratosis With 5% KOH Solution	https://ClinicalTrials.gov/show/NCT04024579	Completed	Infectopharm Arzneimittel GmbH	2019-08-25
NCT01151956	Imiquimod and Actinic Keratoses: an Observational Study	https://ClinicalTrials.gov/show/NCT01151956	Completed	Federal University Teaching Hospital, Feldkirch, Austria	NA
NCT00989313	A Long Term Follow up Study of Patients Who Have Complete Clearance of Their Actinic Keratosis (AK) Lesions at the Day 57 Visit in the PEP005-028 Study	https://ClinicalTrials.gov/show/NCT00989313	Completed	Peplin	2010-10-31
NCT00952783	A Long Term Follow up Study of Patients Who Have Completed the PEP005-020 Study	https://ClinicalTrials.gov/show/NCT00952783	Completed	Peplin	2010-10-31
NCT00953732	A Long Term Follow up Study of Patients Who Have Completed the PEP005-016 or PEP005-025 Studies	https://ClinicalTrials.gov/show/NCT00953732	Completed	Peplin	2010-10-31
NCT00710489	Potential Research Study Participant Registry	https://ClinicalTrials.gov/show/NCT00710489	Completed	University of California, Davis	2018-09-05
NCT00668733	Follow-up Study to Evaluate Sustained Clearance Rates of Actinic Keratoses up to One Year	https://ClinicalTrials.gov/show/NCT00668733	Completed	Graceway Pharmaceuticals, LLC	2009-07-31
NCT00540566	Optical Biopsy of Human Skin in Conjunction With Laser Treatment	https://ClinicalTrials.gov/show/NCT00540566	Completed	University of California, Irvine	2008-06-30
NCT00218868	Cytodiagnosis of Basal Cell Carcinoma and Actinic Keratosis Using Papanicolaou and May-grunwald-giemsa Stained Tissue Smear	https://ClinicalTrials.gov/show/NCT00218868	Completed	Norwegian University of Science and Technology	2006-02-28
NCT00189254	A Study to Follow up Recurrence Rates of Actinic Keratoses One Year After Completion of Study 1487-IMIQ	https://ClinicalTrials.gov/show/NCT00189254	Completed	MEDA Pharma GmbH & Co. KG	2005-11-30
NCT00114023	1-Year Follow up to the 1473-IMIQ Study	https://ClinicalTrials.gov/show/NCT00114023	Completed	Graceway Pharmaceuticals, LLC	NA
NCT00001292	Study of Scaling Disorders and Other Inherited Skin Diseases	https://ClinicalTrials.gov/show/NCT00001292	Completed	National Institutes of Health Clinical Center (CC)	NA
NCT00005660	The Evaluation of Oral Acitretin in the Treatment of Psoriasis, Cutaneous Disorders of Keratinization, Multiple Basal Cell Carcinomas and Other Retinoid Responsive Diseases	https://ClinicalTrials.gov/show/NCT00005660	Completed	National Institutes of Health Clinical Center (CC)	NA

Registries

#If less then 500 registries

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT03319251	Biomarker Database Registry for Photodynamic Therapy	https://ClinicalTrials.gov/show/NCT03319251	Recruiting	The Cleveland Clinic	2021-11-30